Product Data Sheet
Val-Ala-PAB-MMAE
Catalog No. A41355
Val-Ala-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs), comprising the valine-alanine-PAB linker and the cytotoxic agent MMAE. MMAE acts primarily as a potent inhibitor of tubulin, disrupting microtubule dynamics and effectively inducing apoptosis in cancer cells. This reagent is utilized in the development and characterization of ADCs for targeted cancer therapies, enhancing specificity and reducing systemic exposure.
Chemical Information
| Catalog Num | A41355 |
|---|---|
| M. Wt | 1037.33 |
| Formula | C55H88N8O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1912408-92-4 |
| Synonyms | |
| SMILES | C[C@@H](C(N[C@H](C)[C@H](C1=CC=CC=C1)O)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](C)NC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)=O)OC |
Biological Activity
| Description | Val-Ala-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs), comprising the valine-alanine-PAB linker and the cytotoxic agent MMAE. MMAE acts primarily as a potent inhibitor of tubulin, disrupting microtubule dynamics and effectively inducing apoptosis in cancer cells. This reagent is utilized in the development and characterization of ADCs for targeted cancer therapies, enhancing specificity and reducing systemic exposure. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
