Product Data Sheet
TL033 TFA
Catalog No. A41359
TL033 TFA is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a linker that connects bioactive small molecule toxins, facilitating targeted delivery of cytotoxic agents. When conjugated with the Sacituzumab antibody (anti-Trop-2), TL033 TFA enables the synthesis of BT001021, which demonstrates potent anti-cancer activity across various malignancies, including breast cancer, non-small cell lung cancer (NSCLC), and gastric cancer.
Chemical Information
| Catalog Num | A41359 |
|---|---|
| M. Wt | 1630.83 (free base) |
| Formula | C76H103N13O23S2.xC2HF3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2746343-70-2 |
| Synonyms | |
| SMILES | O=C1N2C(C3=NC4=CC=CC=C4C(CCN(C(C)C)S(C)(=O)=O)=C3C2)=CC5=C1COC([C@@]5(CC)OC(OCC6=CC=C(C=C6)NC([C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7C=C(N=N7)CNC(CCCC#CC8=CN=C(S(C)(=O)=O)N=C8)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x] |
Biological Activity
| Description | TL033 TFA is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a linker that connects bioactive small molecule toxins, facilitating targeted delivery of cytotoxic agents. When conjugated with the Sacituzumab antibody (anti-Trop-2), TL033 TFA enables the synthesis of BT001021, which demonstrates potent anti-cancer activity across various malignancies, including breast cancer, non-small cell lung cancer (NSCLC), and gastric cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
