Product Data Sheet
LE01
Catalog No. A41553
LE01 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It incorporates a linker suitable for ADC synthesis and the DNA topoisomerase I inhibitor DXd, facilitating targeted therapy. LE01 is particularly useful in generating HER2-targeting ADCs, enabling selective delivery of cytotoxic agents to HER2-expressing tumors for enhanced therapeutic efficacy.
Chemical Information
| Catalog Num | A41553 |
|---|---|
| M. Wt | 1105.13 |
| Formula | C55H61FN10O14 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2718125-83-6 |
| Synonyms | |
| SMILES | O=C(C=C1)N(CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCCN(C)C(OCC(N[C@H]3CCC4=C5C3=C6C(C(N7C6)=CC([C@@](O)(CC)C(OC8)=O)=C8C7=O)=NC5=CC(F)=C4C)=O)=O)=O)=O)=O)=O)=O)C1=O |
Biological Activity
| Description | LE01 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It incorporates a linker suitable for ADC synthesis and the DNA topoisomerase I inhibitor DXd, facilitating targeted therapy. LE01 is particularly useful in generating HER2-targeting ADCs, enabling selective delivery of cytotoxic agents to HER2-expressing tumors for enhanced therapeutic efficacy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
