Product Data Sheet
DPI-4452
Catalog No. A41618
DPI-4452 is a CAIX-targeting cyclic peptide incorporating a DOTA cage, designed for chelation with radionuclides for positron emission tomography-computed tomography (PET-CT) imaging of CAIX-expressing tumors. This compound exhibits high specificity by binding to the carbonic anhydrase IX (CAIX) with an IC50 of 130 nM, while showing no significant interactions with a panel of 55 off-target receptors. In preclinical studies, radiolabeled DPI-4452 effectively inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models. Additionally, it serves as a valuable reagent for the research and development of Radionuclide-Drug Conjugates (RDCs).
Chemical Information
| Catalog Num | A41618 |
|---|---|
| M. Wt | 2106.36 |
| Formula | C92H132N22O29S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2941391-49-5 |
| Synonyms | |
| SMILES |
Biological Activity
| Description | DPI-4452 is a CAIX-targeting cyclic peptide incorporating a DOTA cage, designed for chelation with radionuclides for positron emission tomography-computed tomography (PET-CT) imaging of CAIX-expressing tumors. This compound exhibits high specificity by binding to the carbonic anhydrase IX (CAIX) with an IC50 of 130 nM, while showing no significant interactions with a panel of 55 off-target receptors. In preclinical studies, radiolabeled DPI-4452 effectively inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models. Additionally, it serves as a valuable reagent for the research and development of Radionuclide-Drug Conjugates (RDCs). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
