Product Data Sheet
GB-6
Catalog No. A41663
GB-6 is a GRPR-targeting peptide that selectively binds to the gastrin releasing peptide receptor, which is frequently overexpressed in pancreatic cancer. This peptide demonstrates excellent in vivo stability and efficacy in tumor targeting and imaging when conjugated with near-infrared fluorescent dyes or the radionuclide technetium-99m (99mTc). In SW1990 subcutaneous xenograft models, GB-6 exhibited tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, facilitating precise tumor boundary delineation. This high-contrast imaging capability positions GB-6 as a promising tool for cancer imaging applications.
Chemical Information
| Catalog Num | A41663 |
|---|---|
| M. Wt | 711.77 |
| Formula | C32H45N11O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2413262-74-3 |
| Synonyms | |
| SMILES | C([C@H](NC([C@H](CCC(N)=O)N)=O)C(NCCC(N[C@H](C(NCC(N[C@@H](CC1=CN=CN1)C(N)=O)=O)=O)CCC)=O)=O)C=2C=3C(NC2)=CC=C(O)C3 |
Biological Activity
| Description | GB-6 is a GRPR-targeting peptide that selectively binds to the gastrin releasing peptide receptor, which is frequently overexpressed in pancreatic cancer. This peptide demonstrates excellent in vivo stability and efficacy in tumor targeting and imaging when conjugated with near-infrared fluorescent dyes or the radionuclide technetium-99m (99mTc). In SW1990 subcutaneous xenograft models, GB-6 exhibited tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, facilitating precise tumor boundary delineation. This high-contrast imaging capability positions GB-6 as a promising tool for cancer imaging applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
