Product Data Sheet
PDM-631
Catalog No. A41761
PDM-631 is a selective inhibitor of phosphodiesterase type 2A (PDE2A) that is both orally active and capable of penetrating the blood-brain barrier. This compound demonstrates potent inhibitory effects, with IC50 values of 1.5 nM against human recombinant PDE2A and 4.2 nM against rat recombinant PDE2A. PDM-631 reliably elevates cGMP levels in the rat cerebral cortex and is valuable for investigating schizophrenia and various neurodegenerative disorders.
Chemical Information
| Catalog Num | A41761 |
|---|---|
| M. Wt | 392.37 |
| Formula | C19H19F3N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2095312-08-4 |
| Synonyms | |
| SMILES | FC(F)(F)OC(C=C1)=CC=C1C[C@@H](N2C3=C(C(N=C(N3)C)=O)C(C4CC4)=N2)C |
Biological Activity
| Description | PDM-631 is a selective inhibitor of phosphodiesterase type 2A (PDE2A) that is both orally active and capable of penetrating the blood-brain barrier. This compound demonstrates potent inhibitory effects, with IC50 values of 1.5 nM against human recombinant PDE2A and 4.2 nM against rat recombinant PDE2A. PDM-631 reliably elevates cGMP levels in the rat cerebral cortex and is valuable for investigating schizophrenia and various neurodegenerative disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
