Product Data Sheet
Zaprinast
Catalog No. A41765
Zaprinast is a selective inhibitor of cGMP-selective Phosphodiesterase 5 (PDE5), leading to a notable increase in cGMP levels in cardiac myocytes. In addition to its PDE5 inhibition, Zaprinast acts as an agonist for G protein-coupled receptor 35 (GPR35), demonstrating strong activation in rat models and moderate activation in human models. This compound exhibits antiproliferative and proapoptotic effects, making it valuable for research applications focused on vascular remodeling and related cardiovascular studies.
Chemical Information
| Catalog Num | A41765 |
|---|---|
| M. Wt | 271.27 |
| Formula | C13H13N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 37762-06-4 |
| Synonyms | M&B 22948 |
| SMILES | O=C1C(N=NN2)=C2N=C(C3=CC=CC=C3OCCC)N1 |
Biological Activity
| Description | Zaprinast is a selective inhibitor of cGMP-selective Phosphodiesterase 5 (PDE5), leading to a notable increase in cGMP levels in cardiac myocytes. In addition to its PDE5 inhibition, Zaprinast acts as an agonist for G protein-coupled receptor 35 (GPR35), demonstrating strong activation in rat models and moderate activation in human models. This compound exhibits antiproliferative and proapoptotic effects, making it valuable for research applications focused on vascular remodeling and related cardiovascular studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
