Product Data Sheet
MR-L2
Catalog No. A41766
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), specifically targeting PDE4A4, PDE4B1, PDE4C3, and PDE4D5 variants. This compound effectively inhibits PGE2-induced cyst formation in MDCK cells, exhibiting an EC50 of 1.2 μM. MR-L2 serves as a valuable tool for studying PDE4-related signaling pathways and exploring potential therapeutic applications in conditions involving dysregulated PDE4 activity.
Chemical Information
| Catalog Num | A41766 |
|---|---|
| M. Wt | 441.71 |
| Formula | C19H16Cl3FN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2374703-19-0 |
| Synonyms | |
| SMILES | ClC1=C(F)C=C(C2=NN(CC(NCC3=CC(Cl)=CC(Cl)=C3)=O)C(CC)=N2)C=C1 |
Biological Activity
| Description | MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), specifically targeting PDE4A4, PDE4B1, PDE4C3, and PDE4D5 variants. This compound effectively inhibits PGE2-induced cyst formation in MDCK cells, exhibiting an EC50 of 1.2 μM. MR-L2 serves as a valuable tool for studying PDE4-related signaling pathways and exploring potential therapeutic applications in conditions involving dysregulated PDE4 activity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
