Product Data Sheet
BC11-38
Catalog No. A41780
BC11-38 is a selective inhibitor of phosphodiesterase 11 (PDE11) with an IC50 of 0.28 µM, demonstrating over 100-fold selectivity against other PDE isoforms (PDE1-10). This compound effectively elevates cyclic AMP (cAMP) levels, enhancing protein kinase A (PKA)-mediated phosphorylation of ATF-1 and stimulating cortisol production in H295R cells. BC11-38 is valuable for research into the regulatory mechanisms of cAMP signaling and its implications in endocrine function.
Chemical Information
| Catalog Num | A41780 |
|---|---|
| M. Wt | 304.43 |
| Formula | C15H16N2OS2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 686770-80-9 |
| Synonyms | |
| SMILES | O=C1C2=C(CCS2)N=C(SCCC)N1C3=CC=CC=C3 |
Biological Activity
| Description | BC11-38 is a selective inhibitor of phosphodiesterase 11 (PDE11) with an IC50 of 0.28 µM, demonstrating over 100-fold selectivity against other PDE isoforms (PDE1-10). This compound effectively elevates cyclic AMP (cAMP) levels, enhancing protein kinase A (PKA)-mediated phosphorylation of ATF-1 and stimulating cortisol production in H295R cells. BC11-38 is valuable for research into the regulatory mechanisms of cAMP signaling and its implications in endocrine function. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
