Product Data Sheet
PF-06445974
Catalog No. A41781
PF-06445974 is a potent phosphodiesterase 4B (PDE4B) inhibitor with an IC50 of less than 1 nM, demonstrating high specificity compared to PDE4 isoforms A, C, and D, with IC50 values of 36 nM, 17 nM, and 4.7 nM, respectively. This radioligand is designed for positron emission tomography (PET) imaging, exhibiting excellent brain permeability and significant specific binding capabilities. PF-06445974 is a valuable tool for researching PDE4B-related neurobiological processes and diseases.
Chemical Information
| Catalog Num | A41781 |
|---|---|
| M. Wt | 346.36 |
| Formula | C20H15FN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2055776-17-3 |
| Synonyms | |
| SMILES | N#CC1=CC=C(C=C1F)C2=C(C3=O)N(CCN3C4CC4)C5=CC=CN=C25 |
Biological Activity
| Description | PF-06445974 is a potent phosphodiesterase 4B (PDE4B) inhibitor with an IC50 of less than 1 nM, demonstrating high specificity compared to PDE4 isoforms A, C, and D, with IC50 values of 36 nM, 17 nM, and 4.7 nM, respectively. This radioligand is designed for positron emission tomography (PET) imaging, exhibiting excellent brain permeability and significant specific binding capabilities. PF-06445974 is a valuable tool for researching PDE4B-related neurobiological processes and diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
