Product Data Sheet
Etazolate hydrochloride
Catalog No. A41786
Etazolate hydrochloride is a selective inhibitor of type 4 phosphodiesterase (PDE4) with a reported IC50 of 2 μM. This compound acts as a γ-aminobutyric acid A (GABAA) receptor modulator and promotes the activation of α-secretase, leading to enhanced production of soluble amyloid precursor protein (sAPPα). As a pyrazolopyridine derivative, Etazolate hydrochloride increases intracellular cAMP levels and exhibits anxiolytic, antidepressant, and anti-inflammatory properties. It is a valuable tool for research applications focused on mood disorders, neurodegenerative diseases, and inflammation.
Chemical Information
| Catalog Num | A41786 |
|---|---|
| M. Wt | 325.79 |
| Formula | C14H20ClN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 35838-58-5 |
| Synonyms | SQ 20009; EHT 0202 hydrochloride |
| SMILES | O=C(C1=CN=C2C(C=NN2CC)=C1N/N=C(C)\C)OCC.Cl |
Biological Activity
| Description | Etazolate hydrochloride is a selective inhibitor of type 4 phosphodiesterase (PDE4) with a reported IC50 of 2 μM. This compound acts as a γ-aminobutyric acid A (GABAA) receptor modulator and promotes the activation of α-secretase, leading to enhanced production of soluble amyloid precursor protein (sAPPα). As a pyrazolopyridine derivative, Etazolate hydrochloride increases intracellular cAMP levels and exhibits anxiolytic, antidepressant, and anti-inflammatory properties. It is a valuable tool for research applications focused on mood disorders, neurodegenerative diseases, and inflammation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
