Product Data Sheet
PF-07038124 hydrochloride
Catalog No. A41807
PF-07038124 hydrochloride is a potent phosphodiesterase 4 (PDE4) inhibitor, exhibiting an IC50 of 0.5 nM for the PDE4B2 isoform. This compound displays significant inhibitory effects on pro-inflammatory cytokines, including IL-13, IL-4, and IFNγ, with IC50 values of 125 nM, 4.1 nM, and 1.06 nM, respectively. PF-07038124 hydrochloride serves as a valuable research tool for studying conditions such as atopic dermatitis and plaque psoriasis, aiding in the exploration of therapeutic interventions targeting inflammatory pathways.
Chemical Information
| Catalog Num | A41807 |
|---|---|
| M. Wt | 363.64 |
| Formula | C18H23BClNO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2415317-57-4 |
| Synonyms | |
| SMILES | [H]Cl.CCCOC1=C(OC)C=CC(C2=CN=CC([C@@]3([H])CB(OC3)O)=C2)=C1 |
Biological Activity
| Description | PF-07038124 hydrochloride is a potent phosphodiesterase 4 (PDE4) inhibitor, exhibiting an IC50 of 0.5 nM for the PDE4B2 isoform. This compound displays significant inhibitory effects on pro-inflammatory cytokines, including IL-13, IL-4, and IFNγ, with IC50 values of 125 nM, 4.1 nM, and 1.06 nM, respectively. PF-07038124 hydrochloride serves as a valuable research tool for studying conditions such as atopic dermatitis and plaque psoriasis, aiding in the exploration of therapeutic interventions targeting inflammatory pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
