Product Data Sheet
Tovinontrine
Catalog No. A41823
Tovinontrine is a selective inhibitor of phosphodiesterase-9 (PDE9) with potent inhibitory activity, displaying IC50 values of 8.19 nM for PDE9A1 and 9.99 nM for PDE9A2. It is primarily researched for its potential therapeutic applications in sickle cell disease due to its ability to modulate intracellular signaling pathways. Studies indicate that Tovinontrine's inhibition of PDE9 may contribute to improved clinical outcomes in this condition.
Chemical Information
| Catalog Num | A41823 |
|---|---|
| M. Wt | 394.47 |
| Formula | C21H26N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2062661-53-2 |
| Synonyms | IMR-687 |
| SMILES | O=C1C2=CN=C(C3CCOCC3)N2C=C([C@@H]4CN(CC5=NC=CC=N5)C[C@H]4C)N1 |
Biological Activity
| Description | Tovinontrine is a selective inhibitor of phosphodiesterase-9 (PDE9) with potent inhibitory activity, displaying IC50 values of 8.19 nM for PDE9A1 and 9.99 nM for PDE9A2. It is primarily researched for its potential therapeutic applications in sickle cell disease due to its ability to modulate intracellular signaling pathways. Studies indicate that Tovinontrine's inhibition of PDE9 may contribute to improved clinical outcomes in this condition. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
