Product Data Sheet
GSK356278
Catalog No. A41824
GSK356278 is a selective phosphodiesterase 4 (PDE4) inhibitor that demonstrates potent activity with pIC50 values of 8.6, 8.8, and 8.7 against human PDE4A, PDE4B, and PDE4D, respectively. This orally bioavailable compound is characterized by its ability to penetrate the blood-brain barrier, exhibiting anti-inflammatory effects alongside anxiolytic and cognition-enhancing properties. GSK356278 is valuable for research in neurodegenerative diseases and mood disorders, making it a significant tool for understanding PDE4 modulation in therapeutic contexts.
Chemical Information
| Catalog Num | A41824 |
|---|---|
| M. Wt | 439.53 |
| Formula | C21H25N7O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 720704-34-7 |
| Synonyms | |
| SMILES | CCN1C2=NC=C(C3=NN=C(CC4=C(C)N=C(C)S4)O3)C(NC5CCOCC5)=C2C=N1 |
Biological Activity
| Description | GSK356278 is a selective phosphodiesterase 4 (PDE4) inhibitor that demonstrates potent activity with pIC50 values of 8.6, 8.8, and 8.7 against human PDE4A, PDE4B, and PDE4D, respectively. This orally bioavailable compound is characterized by its ability to penetrate the blood-brain barrier, exhibiting anti-inflammatory effects alongside anxiolytic and cognition-enhancing properties. GSK356278 is valuable for research in neurodegenerative diseases and mood disorders, making it a significant tool for understanding PDE4 modulation in therapeutic contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
