Product Data Sheet
LEO 39652
Catalog No. A41889
LEO 39652 is a potent dual-selective inhibitor of phosphodiesterase type 4 (PDE4), exhibiting IC50 values of 1.2 nM for PDE4A and PDE4B, 3.0 nM for PDE4C, and 3.8 nM for PDE4D. Additionally, it inhibits TNF-α with an IC50 of 6.0 nM. This compound is primarily utilized in topical research for atopic dermatitis (AD), making it valuable for studies aimed at understanding and developing treatments for this condition.
Chemical Information
| Catalog Num | A41889 |
|---|---|
| M. Wt | 421.45 |
| Formula | C23H23N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1445656-91-6 |
| Synonyms | |
| SMILES | O=C(C1(C2=NN3C(C4=CC5=C(C(OC5)=O)C=C4)=CC=C(OC)C3=N2)CC1)OCC(C)C |
Biological Activity
| Description | LEO 39652 is a potent dual-selective inhibitor of phosphodiesterase type 4 (PDE4), exhibiting IC50 values of 1.2 nM for PDE4A and PDE4B, 3.0 nM for PDE4C, and 3.8 nM for PDE4D. Additionally, it inhibits TNF-α with an IC50 of 6.0 nM. This compound is primarily utilized in topical research for atopic dermatitis (AD), making it valuable for studies aimed at understanding and developing treatments for this condition. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
