Product Data Sheet
Eggmanone
Catalog No. A41914
Eggmanone is a selective antagonist of phosphodiesterase 4 (PDE4), with an IC50 of 72 nM for the PDE4D3 isoform. This compound exhibits a remarkable 40- to 50-fold selectivity for PDE4D3 over other phosphodiesterases. By inhibiting PDE4, Eggmanone activates protein kinase A, resulting in the blockade of Hedgehog (Hh) signaling pathways. This biological activity makes Eggmanone a valuable tool for research into cellular signaling and potential therapeutic applications in conditions mediated by Hh pathways.
Chemical Information
| Catalog Num | A41914 |
|---|---|
| M. Wt | 416.58 |
| Formula | C20H20N2O2S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 505068-32-6 |
| Synonyms | EGM1 |
| SMILES | O=C1N(C(SCC(C2=CC=CS2)=O)=NC3=C1C4=C(CCCC4)S3)CC(C)=C |
Biological Activity
| Description | Eggmanone is a selective antagonist of phosphodiesterase 4 (PDE4), with an IC50 of 72 nM for the PDE4D3 isoform. This compound exhibits a remarkable 40- to 50-fold selectivity for PDE4D3 over other phosphodiesterases. By inhibiting PDE4, Eggmanone activates protein kinase A, resulting in the blockade of Hedgehog (Hh) signaling pathways. This biological activity makes Eggmanone a valuable tool for research into cellular signaling and potential therapeutic applications in conditions mediated by Hh pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
