Product Data Sheet
T-0156
Catalog No. A41919
T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor that disrupts the hydrolysis of cyclic guanosine monophosphate (cGMP) in a competitive manner, with an IC50 value of 0.23 nM. This compound also demonstrates inhibitory effects on PDE6 (IC50=56 nM) while displaying low potency against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 is valuable for research focusing on the nitric oxide (NO)/cGMP signaling pathway, with potential applications in cardiovascular and erectile dysfunction studies.
Chemical Information
| Catalog Num | A41919 |
|---|---|
| M. Wt | 620.05 |
| Formula | C31H30ClN5O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 324572-93-2 |
| Synonyms | |
| SMILES | COC(C(N1CC2=CC=NC(C)=C2)=C(C3=CC(OC)=C(OC)C(OC)=C3)C4=CC=NC(OCC5=NC=CC=N5)=C4C1=O)=O.Cl |
Biological Activity
| Description | T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor that disrupts the hydrolysis of cyclic guanosine monophosphate (cGMP) in a competitive manner, with an IC50 value of 0.23 nM. This compound also demonstrates inhibitory effects on PDE6 (IC50=56 nM) while displaying low potency against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 is valuable for research focusing on the nitric oxide (NO)/cGMP signaling pathway, with potential applications in cardiovascular and erectile dysfunction studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
