Product Data Sheet
PF-07038124
Catalog No. A41930
PF-07038124 is a potent phosphodiesterase 4 (PDE4) inhibitor, exhibiting an IC50 of 0.5 nM for the PDE4B2 isoform. It demonstrates significant inhibitory activity against pro-inflammatory cytokines, including IL-13 (IC50 = 125 nM), IL-4 (IC50 = 4.1 nM), and IFN-γ (IC50 = 1.06 nM). This compound is valuable for research applications related to atopic dermatitis and plaque psoriasis, offering insights into therapeutic strategies for managing these inflammatory conditions.
Chemical Information
| Catalog Num | A41930 |
|---|---|
| M. Wt | 327.18 |
| Formula | C18H22BNO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2415085-44-6 |
| Synonyms | |
| SMILES | CCCOC1=C(OC)C=CC(C2=CN=CC([C@@]3([H])CB(OC3)O)=C2)=C1 |
Biological Activity
| Description | PF-07038124 is a potent phosphodiesterase 4 (PDE4) inhibitor, exhibiting an IC50 of 0.5 nM for the PDE4B2 isoform. It demonstrates significant inhibitory activity against pro-inflammatory cytokines, including IL-13 (IC50 = 125 nM), IL-4 (IC50 = 4.1 nM), and IFN-γ (IC50 = 1.06 nM). This compound is valuable for research applications related to atopic dermatitis and plaque psoriasis, offering insights into therapeutic strategies for managing these inflammatory conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
