Product Data Sheet
Roflumilast-d4
Catalog No. A41932
Roflumilast-d4 is a deuterium-labeled derivative of Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor. This compound exhibits potent inhibitory activity with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, demonstrating its specificity as it does not impact PDE1, PDE2, PDE3, or PDE5 isoenzymes across various cell types. Roflumilast-d4 is primarily used as a stable isotope internal standard in pharmacokinetic studies and drug metabolism research.
Chemical Information
| Catalog Num | A41932 |
|---|---|
| M. Wt | 407.23 |
| Formula | C17H10D4Cl2F2N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1398065-69-4 |
| Synonyms | APTA-2217-d4; BYK 20869-d4; B9302-107-d4 |
| SMILES | FC(OC1=C(C=C(C=C1)C(NC2=C(C=NC=C2Cl)Cl)=O)OCC3C([2H])(C3([2H])[2H])[2H])F |
Biological Activity
| Description | Roflumilast-d4 is a deuterium-labeled derivative of Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor. This compound exhibits potent inhibitory activity with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, demonstrating its specificity as it does not impact PDE1, PDE2, PDE3, or PDE5 isoenzymes across various cell types. Roflumilast-d4 is primarily used as a stable isotope internal standard in pharmacokinetic studies and drug metabolism research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
