Product Data Sheet
PF-04822163
Catalog No. A41933
PF-04822163 is a selective phosphodiesterase 1 (PDE1) inhibitor that effectively crosses the blood-brain barrier, exhibiting IC50 values of 2 nM for PDE1A, 2.4 nM for PDE1B, and 7 nM for PDE1C. This compound demonstrates significant potential for modulating intracellular signaling pathways, making it valuable in the study of neurological disorders such as attention deficit hyperactivity disorder and Parkinson's disease. Its potency and selectivity support its use in preclinical research efforts aimed at elucidating the role of PDE1 in these conditions.
Chemical Information
| Catalog Num | A41933 |
|---|---|
| M. Wt | 340.80 |
| Formula | C19H17ClN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1798334-07-2 |
| Synonyms | |
| SMILES | COC1=C(OC)C=CC2=C([C@H]3CCC4=C3C=C(Cl)C=C4)N=CN=C12 |
Biological Activity
| Description | PF-04822163 is a selective phosphodiesterase 1 (PDE1) inhibitor that effectively crosses the blood-brain barrier, exhibiting IC50 values of 2 nM for PDE1A, 2.4 nM for PDE1B, and 7 nM for PDE1C. This compound demonstrates significant potential for modulating intracellular signaling pathways, making it valuable in the study of neurological disorders such as attention deficit hyperactivity disorder and Parkinson's disease. Its potency and selectivity support its use in preclinical research efforts aimed at elucidating the role of PDE1 in these conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
