Product Data Sheet
Avanafil dibenzenesulfonate
Catalog No. A41935
Avanafil dibenzenesulfonate is a selective phosphodiesterase-5 (PDE-5) inhibitor with a potent IC50 of 5.2 nM for PDE-5, demonstrating significant selectivity against other PDE isoforms. This compound activates the NO/cGMP/PKG signaling pathway, ultimately leading to reduced bone mineral density loss, alleviation of bone atrophy, and decreased oxidative stress. Avanafil dibenzenesulfonate is suitable for research applications related to erectile dysfunction and osteoporosis, where modulation of cGMP levels is crucial.
Chemical Information
| Catalog Num | A41935 |
|---|---|
| M. Wt | 800.30 |
| Formula | C35H38ClN7O9S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 330784-48-0 |
| Synonyms | TA1790 dibenzenesulfonate |
| SMILES | O=C(C1=CN=C(N2[C@H](CO)CCC2)N=C1NCC3=CC=C(OC)C(Cl)=C3)NCC4=NC=CC=N4.O=S(C5=CC=CC=C5)(O)=O.O=S(C6=CC=CC=C6)(O)=O |
Biological Activity
| Description | Avanafil dibenzenesulfonate is a selective phosphodiesterase-5 (PDE-5) inhibitor with a potent IC50 of 5.2 nM for PDE-5, demonstrating significant selectivity against other PDE isoforms. This compound activates the NO/cGMP/PKG signaling pathway, ultimately leading to reduced bone mineral density loss, alleviation of bone atrophy, and decreased oxidative stress. Avanafil dibenzenesulfonate is suitable for research applications related to erectile dysfunction and osteoporosis, where modulation of cGMP levels is crucial. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
