Product Data Sheet
NPD-1335
Catalog No. A41936
NPD-1335 is an inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), demonstrating submicromolar efficacy against T. brucei parasites. This compound enhances intracellular cAMP levels, leading to cell cycle disruption and apoptosis in the target cells. Additionally, NPD-1335 features an alkyne moiety, enabling its use as a click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, thus expanding its utility in various research applications.
Chemical Information
| Catalog Num | A41936 |
|---|---|
| M. Wt | 455.55 |
| Formula | C28H29N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2376326-31-5 |
| Synonyms | |
| SMILES | O=C(NCC1=CC=CC=C1)C#CC2=CC(C3=NN(C(C)C)C([C@@]4([H])CC=CC[C@@]34[H])=O)=CC=C2OC |
Biological Activity
| Description | NPD-1335 is an inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), demonstrating submicromolar efficacy against T. brucei parasites. This compound enhances intracellular cAMP levels, leading to cell cycle disruption and apoptosis in the target cells. Additionally, NPD-1335 features an alkyne moiety, enabling its use as a click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, thus expanding its utility in various research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
