Product Data Sheet
ID11916
Catalog No. A41947
ID11916 is an orally active antagonist of the androgen receptor (AR) and a phosphodiesterase 5 (PDE5) inhibitor. It effectively inhibits androgen binding to AR, prevents nuclear translocation, and suppresses androgen-dependent transcriptional activity. Additionally, ID11916 elevates intracellular cGMP levels and activates protein kinase G (PKG) through its inhibitory effects. This compound demonstrates significant anti-cancer activity against prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell lines such as SK-BR-3, making it a valuable tool for cancer research.
Chemical Information
| Catalog Num | A41947 |
|---|---|
| M. Wt | 624.64 |
| Formula | C29H27F3N8O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2785317-21-5 |
| Synonyms | |
| SMILES | O=C1C(C)(N(C(N1C2=CN=C(C(C(F)(F)F)=C2)C#N)=S)C3=CC=C(C(C4=NN5C(C(N4)=O)=C(N=C5CCC)C)=C3)OCC)C |
Biological Activity
| Description | ID11916 is an orally active antagonist of the androgen receptor (AR) and a phosphodiesterase 5 (PDE5) inhibitor. It effectively inhibits androgen binding to AR, prevents nuclear translocation, and suppresses androgen-dependent transcriptional activity. Additionally, ID11916 elevates intracellular cGMP levels and activates protein kinase G (PKG) through its inhibitory effects. This compound demonstrates significant anti-cancer activity against prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell lines such as SK-BR-3, making it a valuable tool for cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
