Product Data Sheet
OPC 33540
Catalog No. A41954
OPC-33540 is a highly selective and competitive inhibitor of phosphodiesterase 3 (PDE3), exhibiting IC50 values of 0.32 nM for PDE3A and 1.5 nM for PDE3B. This compound demonstrates significantly reduced activity against other phosphodiesterases, with IC50 values ranging from 42.9 μM to 100.8 μM for PDE1, PDE2, PDE4, PDE5, and PDE7. OPC-33540 effectively increases cAMP levels in platelets and inhibits thrombin-induced platelet aggregation, making it a valuable tool for antithrombotic research applications.
Chemical Information
| Catalog Num | A41954 |
|---|---|
| M. Wt | 469.62 |
| Formula | C27H39N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 189362-27-4 |
| Synonyms | |
| SMILES | O=C(NCCCOC1=CC2=C(NC(C=C2)=O)C=C1)N(C3CCCCCCC3)[C@H]4[C@H](O)CCCC4 |
Biological Activity
| Description | OPC-33540 is a highly selective and competitive inhibitor of phosphodiesterase 3 (PDE3), exhibiting IC50 values of 0.32 nM for PDE3A and 1.5 nM for PDE3B. This compound demonstrates significantly reduced activity against other phosphodiesterases, with IC50 values ranging from 42.9 μM to 100.8 μM for PDE1, PDE2, PDE4, PDE5, and PDE7. OPC-33540 effectively increases cAMP levels in platelets and inhibits thrombin-induced platelet aggregation, making it a valuable tool for antithrombotic research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
