Product Data Sheet
PDE4-IN-34
Catalog No. A41970
PDE4-IN-34 is a selective phosphodiesterase 4 (PDE4) inhibitor, demonstrating IC50 values of 19 pM and 14 pM for PDE4B1 and PDE4D2, respectively. This compound shows weak inhibitory activity against PDE8A1 (IC50 of 4.092 μM) and exhibits significant selectivity over other PDE subtypes (IC50 > 10 μM). PDE4-IN-34 effectively improves pulmonary function, reduces inflammatory responses, and mitigates lung tissue damage in rat models of chronic obstructive pulmonary disease induced by cigarette smoke and LPS. It serves as a valuable tool for research into PDE4-related pathways in pulmonary disorders.
Chemical Information
| Catalog Num | A41970 |
|---|---|
| M. Wt | 381.64 |
| Formula | C17H11Cl3N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3052591-16-6 |
| Synonyms | |
| SMILES | ClC1=NC2=C(C(C(CC3=C(C=NC=C3Cl)Cl)=O)=CC=C2OC)C=C1 |
Biological Activity
| Description | PDE4-IN-34 is a selective phosphodiesterase 4 (PDE4) inhibitor, demonstrating IC50 values of 19 pM and 14 pM for PDE4B1 and PDE4D2, respectively. This compound shows weak inhibitory activity against PDE8A1 (IC50 of 4.092 μM) and exhibits significant selectivity over other PDE subtypes (IC50 > 10 μM). PDE4-IN-34 effectively improves pulmonary function, reduces inflammatory responses, and mitigates lung tissue damage in rat models of chronic obstructive pulmonary disease induced by cigarette smoke and LPS. It serves as a valuable tool for research into PDE4-related pathways in pulmonary disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
