Product Data Sheet
PDE4-IN-29
Catalog No. A42010
PDE4-IN-29 is a selective phosphodiesterase 4 (PDE4) inhibitor, with sub-nanomolar potency against PDE4D3, exhibiting IC50 values of less than 5 nM. By inhibiting the degradation of cyclic adenosine monophosphate (cAMP), PDE4-IN-29 effectively elevates intracellular cAMP levels, leading to a reduction in inflammatory cytokine release, including TNF-α. This compound is of great interest for investigating inflammatory diseases such as psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease.
Chemical Information
| Catalog Num | A42010 |
|---|---|
| M. Wt | 546.63 |
| Formula | C27H34N2O8S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2815361-45-4 |
| Synonyms | |
| SMILES | O=C1N([C@@H](C2=CC(OCC)=C(OC)C=C2)CS(C)(=O)=O)C(C3=C(NC(C)=O)C=CC(C(CCCC)O)=C31)=O |
Biological Activity
| Description | PDE4-IN-29 is a selective phosphodiesterase 4 (PDE4) inhibitor, with sub-nanomolar potency against PDE4D3, exhibiting IC50 values of less than 5 nM. By inhibiting the degradation of cyclic adenosine monophosphate (cAMP), PDE4-IN-29 effectively elevates intracellular cAMP levels, leading to a reduction in inflammatory cytokine release, including TNF-α. This compound is of great interest for investigating inflammatory diseases such as psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
