Product Data Sheet
Tolafentrine
Catalog No. A42038
Tolafentrine is a dual-selective phosphodiesterase 3 and 4 (PDE3/4) inhibitor that exhibits significant therapeutic potential in managing pulmonary hypertension. In studies utilizing a unilateral diacetamide-induced rat model, Tolafentrine demonstrated the ability to alleviate hemodynamic and gas exchange abnormalities associated with the condition. Additionally, long-term administration was shown to reduce right ventricular hypertrophy and normalize pulmonary vascular remodeling, highlighting its relevance in cardiovascular research and potential therapeutic applications.
Chemical Information
| Catalog Num | A42038 |
|---|---|
| M. Wt | 505.63 |
| Formula | C28H31N3O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 139308-65-9 |
| Synonyms | |
| SMILES | [H][C@@]12CN(CC[C@@]1(N=C(C3=C2C=C(C(OC)=C3)OC)C4=CC=C(C=C4)NS(C5=CC=C(C=C5)C)(=O)=O)[H])C |
Biological Activity
| Description | Tolafentrine is a dual-selective phosphodiesterase 3 and 4 (PDE3/4) inhibitor that exhibits significant therapeutic potential in managing pulmonary hypertension. In studies utilizing a unilateral diacetamide-induced rat model, Tolafentrine demonstrated the ability to alleviate hemodynamic and gas exchange abnormalities associated with the condition. Additionally, long-term administration was shown to reduce right ventricular hypertrophy and normalize pulmonary vascular remodeling, highlighting its relevance in cardiovascular research and potential therapeutic applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
