Product Data Sheet
DNS-8254
Catalog No. A42047
DNS-8254 is a potent inhibitor of phosphodiesterase 2A (PDE2a) with an IC50 of 8 nM, demonstrating significant oral bioavailability and the capability to penetrate the blood-brain barrier. This compound is associated with memory-enhancing effects in rodent models, making it a valuable tool for research into cognitive function and related disorders. Its mechanism suggests potential applications in the study of neurodegenerative diseases and cognitive impairments.
Chemical Information
| Catalog Num | A42047 |
|---|---|
| M. Wt | 454.24 |
| Formula | C18H15BrF3N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1821107-98-5 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(F)C(Br)=C1)N2CC(F)(F)C[C@H](C3=CC(C)=NC4=NC=NN34)C2 |
Biological Activity
| Description | DNS-8254 is a potent inhibitor of phosphodiesterase 2A (PDE2a) with an IC50 of 8 nM, demonstrating significant oral bioavailability and the capability to penetrate the blood-brain barrier. This compound is associated with memory-enhancing effects in rodent models, making it a valuable tool for research into cognitive function and related disorders. Its mechanism suggests potential applications in the study of neurodegenerative diseases and cognitive impairments. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
