Product Data Sheet
EHNA
Catalog No. A42057
EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA). It exhibits significant inhibition of cGMP-stimulated PDE2 activity, with an IC50 of 0.8 μM in human samples and 2 μM in porcine myocardium, while showing lesser effects on unstimulated PDE2. EHNA has been implicated in mediating various pharmacological responses, including antiviral, antitumor, and antiarrhythmic activities, making it a valuable tool for research in these domains.
Chemical Information
| Catalog Num | A42057 |
|---|---|
| M. Wt | 277.37 |
| Formula | C14H23N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 51350-19-7 |
| Synonyms | |
| SMILES | CCCCCC[C@@](N1C2=C(C(N)=NC=N2)N=C1)([H])[C@H](O)C |
Biological Activity
| Description | EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA). It exhibits significant inhibition of cGMP-stimulated PDE2 activity, with an IC50 of 0.8 μM in human samples and 2 μM in porcine myocardium, while showing lesser effects on unstimulated PDE2. EHNA has been implicated in mediating various pharmacological responses, including antiviral, antitumor, and antiarrhythmic activities, making it a valuable tool for research in these domains. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
