Product Data Sheet
KCA-1490
Catalog No. A42060
KCA-1490 is a dual inhibitor of phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4), exhibiting IC50 values of 369 nM and 42 nM, respectively. This compound demonstrates significant bronchodilatory and anti-inflammatory effects, effectively suppressing histamine-induced bronchoconstriction in vivo. KCA-1490 is a valuable tool for research into asthma and chronic obstructive pulmonary disease (COPD) pathways and therapeutic strategies.
Chemical Information
| Catalog Num | A42060 |
|---|---|
| M. Wt | 326.27 |
| Formula | C14H13F3N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 909719-71-7 |
| Synonyms | |
| SMILES | O=C1CC(C)C(C2=CC=C(OC)N3C2=CC(C(F)(F)F)=N3)=NN1 |
Biological Activity
| Description | KCA-1490 is a dual inhibitor of phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4), exhibiting IC50 values of 369 nM and 42 nM, respectively. This compound demonstrates significant bronchodilatory and anti-inflammatory effects, effectively suppressing histamine-induced bronchoconstriction in vivo. KCA-1490 is a valuable tool for research into asthma and chronic obstructive pulmonary disease (COPD) pathways and therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
