Product Data Sheet
PF-04677490
Catalog No. A42076
PF-04677490 is a potent inhibitor of phosphodiesterase 1 (PDE1), with IC50 values of 21 nM, 83 nM, and 118 nM for PDE1B1, PDE1C, and PDE1A, respectively. This compound effectively inhibits the hydrolytic activity of cAMP and cGMP, making it a valuable tool for investigating signaling pathways mediated by cyclic nucleotides. PF-04677490 is suitable for research applications focused on cardiovascular, neurological, and inflammatory diseases.
Chemical Information
| Catalog Num | A42076 |
|---|---|
| M. Wt | 327.38 |
| Formula | C17H21N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1628342-10-8 |
| Synonyms | |
| SMILES | CC(CC1=NNC(C)=C1)NC2=C3C=CC(OC)=C(C3=NC=N2)OC |
Biological Activity
| Description | PF-04677490 is a potent inhibitor of phosphodiesterase 1 (PDE1), with IC50 values of 21 nM, 83 nM, and 118 nM for PDE1B1, PDE1C, and PDE1A, respectively. This compound effectively inhibits the hydrolytic activity of cAMP and cGMP, making it a valuable tool for investigating signaling pathways mediated by cyclic nucleotides. PF-04677490 is suitable for research applications focused on cardiovascular, neurological, and inflammatory diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
