Product Data Sheet
SAL-0010042
Catalog No. A42081
SAL-0010042 is a potent inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP with an IC50 of 48.9 nM in gametocytes. This compound activates protein kinase G (PKG) and demonstrates significant inhibitory effects on the growth and development of Plasmodium, with IC50 values of 142 nM and 218 nM for the 3D7 and Dd2 strains, respectively. Additionally, SAL-0010042 also inhibits human phosphodiesterases hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, making it valuable for research in malaria and related diseases.
Chemical Information
| Catalog Num | A42081 |
|---|---|
| M. Wt | 286.30 |
| Formula | C15H15FN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 521298-46-4 |
| Synonyms | |
| SMILES | O=C1N=C(CC2=C(F)C=CC=C2)NC3=C1NN=C3C(C)C |
Biological Activity
| Description | SAL-0010042 is a potent inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP with an IC50 of 48.9 nM in gametocytes. This compound activates protein kinase G (PKG) and demonstrates significant inhibitory effects on the growth and development of Plasmodium, with IC50 values of 142 nM and 218 nM for the 3D7 and Dd2 strains, respectively. Additionally, SAL-0010042 also inhibits human phosphodiesterases hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, making it valuable for research in malaria and related diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
