Product Data Sheet
NVP-ABE171
Catalog No. A42094
NVP-ABE171 is a potent, orally active inhibitor of phosphodiesterase 4 (PDE4) that exhibits selective IC50 values of 1.5 nM for PDE4D, 34 nM for PDE4B, 602 nM for PDE4A, and 1230 nM for PDE4C. This compound significantly increases cAMP levels in response to isoproterenol, while also inhibiting eosinophil oxidative bursts and inflammatory cytokine release from T cells and monocytes. NVP-ABE171 demonstrates strong anti-inflammatory effects in preclinical models of asthma and pulmonary inflammation, making it a valuable tool for studying asthma and chronic obstructive pulmonary disease.
Chemical Information
| Catalog Num | A42094 |
|---|---|
| M. Wt | 368.34 |
| Formula | C21H12N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 426268-06-6 |
| Synonyms | |
| SMILES | O=C(O)C1=CC=C(C2=NC(C3=CC4=NON=C4C=C3)=C5N=CC=CC5=C2)C=C1 |
Biological Activity
| Description | NVP-ABE171 is a potent, orally active inhibitor of phosphodiesterase 4 (PDE4) that exhibits selective IC50 values of 1.5 nM for PDE4D, 34 nM for PDE4B, 602 nM for PDE4A, and 1230 nM for PDE4C. This compound significantly increases cAMP levels in response to isoproterenol, while also inhibiting eosinophil oxidative bursts and inflammatory cytokine release from T cells and monocytes. NVP-ABE171 demonstrates strong anti-inflammatory effects in preclinical models of asthma and pulmonary inflammation, making it a valuable tool for studying asthma and chronic obstructive pulmonary disease. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
