Product Data Sheet
(-)-Pimobendan
Catalog No. A42117
(-)-Pimobendan selectively targets phosphodiesterase (PDE), enhancing cyclic nucleotide signaling. This isomer exhibits a pronounced affinity for erythrocytes, leading to a significantly lower clearance rate compared to its counterpart. Notably, (-)-pimobendan demonstrates a 1.5-fold increase in contractile force in detergent-treated myocardial specimens from guinea pigs and dogs. These distinctive pharmacokinetic properties may provide unique advantages for its application in clinical settings, particularly in cardiac research and therapeutics.
Chemical Information
| Catalog Num | A42117 |
|---|---|
| M. Wt | 334.37 |
| Formula | C19H18N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 118428-37-8 |
| Synonyms | (-)-UD-CG115 |
| SMILES | O=C1CC(C)C(C2=CC=C3C(N=C(C4=CC=C(OC)C=C4)N3)=C2)=NN1.[Rotation (-)] |
Biological Activity
| Description | (-)-Pimobendan selectively targets phosphodiesterase (PDE), enhancing cyclic nucleotide signaling. This isomer exhibits a pronounced affinity for erythrocytes, leading to a significantly lower clearance rate compared to its counterpart. Notably, (-)-pimobendan demonstrates a 1.5-fold increase in contractile force in detergent-treated myocardial specimens from guinea pigs and dogs. These distinctive pharmacokinetic properties may provide unique advantages for its application in clinical settings, particularly in cardiac research and therapeutics. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
