Product Data Sheet
PDE3/4-IN-2
Catalog No. A42150
PDE3/4-IN-2 is a potent dual inhibitor of phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4), demonstrating IC50 values of 0.13 nM for PDE3A and 50 nM for PDE4B1. This compound is valuable in the investigation of diseases related to phosphodiesterase dysregulation, including asthma, chronic obstructive pulmonary disease, sepsis, and nephritis. Its selective inhibition profile makes it a significant tool for exploring therapeutic strategies in these conditions.
Chemical Information
| Catalog Num | A42150 |
|---|---|
| M. Wt | 503.59 |
| Formula | C28H33N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2857007-03-3 |
| Synonyms | |
| SMILES | O=C1N=C(N(CCN2C(NCC2)=O)C3=C(C)C=C(C)C=C3C)C=C4C5=C(CCN14)C=C(OC)C(OC)=C5 |
Biological Activity
| Description | PDE3/4-IN-2 is a potent dual inhibitor of phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4), demonstrating IC50 values of 0.13 nM for PDE3A and 50 nM for PDE4B1. This compound is valuable in the investigation of diseases related to phosphodiesterase dysregulation, including asthma, chronic obstructive pulmonary disease, sepsis, and nephritis. Its selective inhibition profile makes it a significant tool for exploring therapeutic strategies in these conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
