Product Data Sheet
PF-03049423
Catalog No. A42174
PF-03049423 is a potent and highly selective inhibitor of phosphodiesterase-5A (PDE5A), demonstrating an IC50 of approximately 0.2 nM for both rat and human platelet enzymes. This compound is primarily used in research related to acute ischemic stroke, providing valuable insights into the therapeutic potential of PDE5A modulation in cerebrovascular conditions. Its specificity and potency make it a critical tool for exploring the role of phosphodiesterase inhibition in neuroprotection and recovery following ischemic events.
Chemical Information
| Catalog Num | A42174 |
|---|---|
| M. Wt | |
| Formula | C24H32N6O4.xHCl |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 402955-58-2 |
| Synonyms | |
| SMILES | O=C1C(N2CCN(CC2)CCO)=NC3=C(N1CCOCCC)C=C(C4=CC=C(OC)N=C4)N=C3.[x HCl] |
Biological Activity
| Description | PF-03049423 is a potent and highly selective inhibitor of phosphodiesterase-5A (PDE5A), demonstrating an IC50 of approximately 0.2 nM for both rat and human platelet enzymes. This compound is primarily used in research related to acute ischemic stroke, providing valuable insights into the therapeutic potential of PDE5A modulation in cerebrovascular conditions. Its specificity and potency make it a critical tool for exploring the role of phosphodiesterase inhibition in neuroprotection and recovery following ischemic events. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
