Product Data Sheet
PDE4/5-IN-1
Catalog No. A42176
PDE4/5-IN-1 is a selective inhibitor targeting phosphodiesterase 4 and 5 (PDE4/5). This compound effectively inhibits the activity of PDE5, PDE4B2, and PDE4D2, leading to relaxation of isolated rat prostate tissue and enhanced nitric oxide-induced relaxation. Additionally, PDE4/5-IN-1 reduces alpha-1 adrenoceptor-mediated contractile responses and inhibits the proliferation of human hyperplastic prostate cells. It is a valuable tool for research into benign prostatic hyperplasia.
Chemical Information
| Catalog Num | A42176 |
|---|---|
| M. Wt | 433.41 |
| Formula | C23H19N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1807631-43-1 |
| Synonyms | |
| SMILES | O=C1CN(CCO)C(C2=C(C3=CNC4=C3C=CC=C4)OC(C5=CC=C(OCO6)C6=C5)N21)=O |
Biological Activity
| Description | PDE4/5-IN-1 is a selective inhibitor targeting phosphodiesterase 4 and 5 (PDE4/5). This compound effectively inhibits the activity of PDE5, PDE4B2, and PDE4D2, leading to relaxation of isolated rat prostate tissue and enhanced nitric oxide-induced relaxation. Additionally, PDE4/5-IN-1 reduces alpha-1 adrenoceptor-mediated contractile responses and inhibits the proliferation of human hyperplastic prostate cells. It is a valuable tool for research into benign prostatic hyperplasia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
