Product Data Sheet
PDE1-IN-4
Catalog No. A42177
PDE1-IN-4 is a selective inhibitor of phosphodiesterase-1 (PDE1), demonstrating IC50 values of 10 nM, 145 nM, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. This compound effectively inhibits the TGF-β1-induced differentiation of human lung fibroblasts into myofibroblasts, showcasing its potential in anti-fibrosis research. By modulating the levels of cAMP and cGMP, PDE1-IN-4 serves as a valuable tool for investigating therapeutic strategies in idiopathic pulmonary fibrosis (IPF).
Chemical Information
| Catalog Num | A42177 |
|---|---|
| M. Wt | 535.63 |
| Formula | C33H33N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3031349-98-8 |
| Synonyms | |
| SMILES | CC1=C(C(C2=CC3=C(C=C2)N(N=C3)C)C(C(O[C@@H](C4=CC=CC=C4)C)=O)=C(N1)C)C(O[C@@H](C5=CC=CC=C5)C)=O |
Biological Activity
| Description | PDE1-IN-4 is a selective inhibitor of phosphodiesterase-1 (PDE1), demonstrating IC50 values of 10 nM, 145 nM, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. This compound effectively inhibits the TGF-β1-induced differentiation of human lung fibroblasts into myofibroblasts, showcasing its potential in anti-fibrosis research. By modulating the levels of cAMP and cGMP, PDE1-IN-4 serves as a valuable tool for investigating therapeutic strategies in idiopathic pulmonary fibrosis (IPF). |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
