Product Data Sheet

Ronomilast

Catalog No. A42189

main product photo
Ronomilast is a potent phosphodiesterase-4 (PDE4) inhibitor, exhibiting an IC50 of 3 nM. This compound is primarily utilized in research focused on inflammation-related diseases. By inhibiting PDE4, Ronomilast increases intracellular cyclic AMP levels, thereby modulating inflammatory responses and offering insights into therapeutic strategies for various inflammatory conditions.
Chemical Information
Catalog NumA42189
M. Wt445.27
FormulaC21H15Cl2FN4O2
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.418794-42-0
SynonymsElbimilast; ELB353
SMILESFC1=CC=C(CN2C(N=CC=C3)C3=C(C(C(NC4=C(Cl)C=NC=C4Cl)=O)=O)C2)C=C1
Biological Activity
DescriptionRonomilast is a potent phosphodiesterase-4 (PDE4) inhibitor, exhibiting an IC50 of 3 nM. This compound is primarily utilized in research focused on inflammation-related diseases. By inhibiting PDE4, Ronomilast increases intracellular cyclic AMP levels, thereby modulating inflammatory responses and offering insights into therapeutic strategies for various inflammatory conditions.
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