Product Data Sheet
T-0156 free base
Catalog No. A42227
T-0156 free base is a selective inhibitor of phosphodiesterase type 5 (PDE5), functioning through competitive inhibition of cyclic guanosine monophosphate (cGMP) hydrolysis, with an IC50 of 0.23 nM. In addition to its primary target, T-0156 exhibits some inhibitory activity against PDE6 with an IC50 of 56 nM, while demonstrating low potency against other PDEs, including PDE1, PDE2, PDE3, and PDE4 (IC50 > 10 μM). This compound plays a valuable role in enhancing the nitric oxide (NO)/cGMP signaling pathway, making it suitable for research in vascular biology and therapies related to erectile dysfunction and pulmonary hypertension.
Chemical Information
| Catalog Num | A42227 |
|---|---|
| M. Wt | 583.59 |
| Formula | C31H29N5O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 324572-92-1 |
| Synonyms | |
| SMILES | O=C(C1=C(C2=CC(OC)=C(OC)C(OC)=C2)C3=CC=NC(OCC4=NC=CC=N4)=C3C(N1CC5=CC(C)=NC=C5)=O)OC |
Biological Activity
| Description | T-0156 free base is a selective inhibitor of phosphodiesterase type 5 (PDE5), functioning through competitive inhibition of cyclic guanosine monophosphate (cGMP) hydrolysis, with an IC50 of 0.23 nM. In addition to its primary target, T-0156 exhibits some inhibitory activity against PDE6 with an IC50 of 56 nM, while demonstrating low potency against other PDEs, including PDE1, PDE2, PDE3, and PDE4 (IC50 > 10 μM). This compound plays a valuable role in enhancing the nitric oxide (NO)/cGMP signaling pathway, making it suitable for research in vascular biology and therapies related to erectile dysfunction and pulmonary hypertension. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
