Product Data Sheet
AC-SDKP-NH2
Catalog No. A42356
AC-SDKP-NH2 is a substrate peptide of Angiotensin-converting enzyme (ACE). It exhibits significant anti-inflammatory and anti-fibrotic activities by directly targeting tissues, thereby preventing or reversing excessive fibrosis without impacting blood pressure or left ventricular hypertrophy (LVH). AC-SDKP-NH2 effectively attenuates inflammation, as well as cell differentiation, proliferation, and migration, resulting in reduced fibrosis in cardiac, vascular, and renal tissues in mouse models. This reagent is applicable in cardiovascular research, particularly in studies related to hypertension and fibrosis-associated conditions.
Chemical Information
| Catalog Num | A42356 |
|---|---|
| M. Wt | 486.52 |
| Formula | C20H34N6O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 194484-75-8 |
| Synonyms | |
| SMILES | C([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CO)=O)CC(O)=O)=O)CCCCN)(=O)N1[C@H](C(N)=O)CCC1 |
Biological Activity
| Description | AC-SDKP-NH2 is a substrate peptide of Angiotensin-converting enzyme (ACE). It exhibits significant anti-inflammatory and anti-fibrotic activities by directly targeting tissues, thereby preventing or reversing excessive fibrosis without impacting blood pressure or left ventricular hypertrophy (LVH). AC-SDKP-NH2 effectively attenuates inflammation, as well as cell differentiation, proliferation, and migration, resulting in reduced fibrosis in cardiac, vascular, and renal tissues in mouse models. This reagent is applicable in cardiovascular research, particularly in studies related to hypertension and fibrosis-associated conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
