Product Data Sheet
IRW
Catalog No. A42368
IRW is an orally active tripeptide derived from egg white, known for its angiotensin-converting enzyme (ACE) inhibitory properties. This compound exhibits significant potential in preventing high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and enhancing mitochondrial content. IRW has been shown to reduce hepatic triglyceride levels and lipid droplet size, while also increasing the activity of mitochondrial complexes and citrate synthase. Its ability to activate key pathways, including phosphorylation of 5’-AMP-activated protein kinase and increasing microsomal triglyceride transfer protein abundance, makes IRW a valuable reagent for studies in inflammation and metabolic disorders.
Chemical Information
| Catalog Num | A42368 |
|---|---|
| M. Wt | 473.57 |
| Formula | C23H35N7O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 159718-10-2 |
| Synonyms | |
| SMILES | O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O)=O)[C@H]([C@@H](C)CC)N |
Biological Activity
| Description | IRW is an orally active tripeptide derived from egg white, known for its angiotensin-converting enzyme (ACE) inhibitory properties. This compound exhibits significant potential in preventing high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and enhancing mitochondrial content. IRW has been shown to reduce hepatic triglyceride levels and lipid droplet size, while also increasing the activity of mitochondrial complexes and citrate synthase. Its ability to activate key pathways, including phosphorylation of 5’-AMP-activated protein kinase and increasing microsomal triglyceride transfer protein abundance, makes IRW a valuable reagent for studies in inflammation and metabolic disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
