Product Data Sheet
EN450
Catalog No. A42445
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. By engaging with allosteric C111 in the E2 ubiquitin ligase UBE2D, EN450 facilitates the formation of a ternary complex involving UBE2D and NFKB1. This interaction leads to the degradation of NF-κB, resulting in notable anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism. EN450 serves as a valuable tool for research involving NF-κB signaling and its implications in cancer biology.
Chemical Information
| Catalog Num | A42445 |
|---|---|
| M. Wt | 288.76 |
| Formula | C11H13ClN2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 793719-01-4 |
| Synonyms | |
| SMILES | O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C |
Biological Activity
| Description | EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. By engaging with allosteric C111 in the E2 ubiquitin ligase UBE2D, EN450 facilitates the formation of a ternary complex involving UBE2D and NFKB1. This interaction leads to the degradation of NF-κB, resulting in notable anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism. EN450 serves as a valuable tool for research involving NF-κB signaling and its implications in cancer biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
