Product Data Sheet
N3-PEG3-CH2CH2COOH
Catalog No. A42581
N3-PEG3-CH2CH2COOH is a PEG-based PROTAC linker that facilitates selective protein degradation by enabling the synthesis of specific PROTACs, including BI-3663 and BI-4216. This compound contains an azide group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-containing molecules. N3-PEG3-CH2CH2COOH is also applicable as a non-cleavable ADC linker in the development of antibody-drug conjugates, making it a versatile reagent for chemical biology research.
Chemical Information
| Catalog Num | A42581 |
|---|---|
| M. Wt | 247.25 |
| Formula | C9H17N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1056024-94-2 |
| Synonyms | |
| SMILES | O=C(O)CCOCCOCCOCCN=[N+]=[N-] |
Biological Activity
| Description | N3-PEG3-CH2CH2COOH is a PEG-based PROTAC linker that facilitates selective protein degradation by enabling the synthesis of specific PROTACs, including BI-3663 and BI-4216. This compound contains an azide group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-containing molecules. N3-PEG3-CH2CH2COOH is also applicable as a non-cleavable ADC linker in the development of antibody-drug conjugates, making it a versatile reagent for chemical biology research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
