Product Data Sheet
Fmoc-Lys(Pal-Glu-OtBu)-OH
Catalog No. A42734
Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs). This compound features a lysine residue with a palmitic acid-modified glutamic acid and tert-butyl ester, providing enhanced stability and solubility. Its structure also allows for use as an alkyl chain-based linker in the development of proteolysis-targeting chimeras (PROTACs), facilitating targeted protein degradation in various research applications. This versatility makes it a valuable reagent for advanced bioconjugation techniques and drug delivery systems.
Chemical Information
| Catalog Num | A42734 |
|---|---|
| M. Wt | 792.06 |
| Formula | C46H69N3O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1491158-62-3 |
| Synonyms | |
| SMILES | CCCCCCCCCCCCCCCC(N[C@H](C(OC(C)(C)C)=O)CCC(NCCCC[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)C(O)=O)=O)=O |
Biological Activity
| Description | Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs). This compound features a lysine residue with a palmitic acid-modified glutamic acid and tert-butyl ester, providing enhanced stability and solubility. Its structure also allows for use as an alkyl chain-based linker in the development of proteolysis-targeting chimeras (PROTACs), facilitating targeted protein degradation in various research applications. This versatility makes it a valuable reagent for advanced bioconjugation techniques and drug delivery systems. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
