Product Data Sheet
DBCO-PEG2-Val-Cit-PAB-MMAE
Catalog No. A42814
DBCO-PEG2-Val-Cit-PAB-MMAE is an antibody-drug conjugate (ADC) linker that employs a DBCO group for efficient click chemistry with azide moieties. This reagent incorporates a Val-Cit dipeptide, which is cleavable by proteases, facilitating the targeted release of the MMAE warhead within cells through an elimination mechanism. Its design is optimized for applications in targeted cancer therapy, enhancing the specificity and efficacy of drug delivery systems.
Chemical Information
| Catalog Num | A42814 |
|---|---|
| M. Wt | 1569.92 |
| Formula | C84H120N12O17 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2845934-59-8 |
| Synonyms | |
| SMILES | O=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(CCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O)=O)=O)=O)=O)=O)=O |
Biological Activity
| Description | DBCO-PEG2-Val-Cit-PAB-MMAE is an antibody-drug conjugate (ADC) linker that employs a DBCO group for efficient click chemistry with azide moieties. This reagent incorporates a Val-Cit dipeptide, which is cleavable by proteases, facilitating the targeted release of the MMAE warhead within cells through an elimination mechanism. Its design is optimized for applications in targeted cancer therapy, enhancing the specificity and efficacy of drug delivery systems. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
