Product Data Sheet
Mal-amide-PEG8-Val-Cit-PAB-OH
Catalog No. A43346
Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker designed to facilitate targeted drug delivery in antibody-drug conjugates. The maleimide group enables covalent attachment to free thiols present on cysteine residues in proteins, while the hydrophilic PEG spacer enhances solubility and reduces immunogenicity. Upon internalization, the Val-Cit dipeptide is cleaved by cellular proteases, allowing for the efficient release of the therapeutic payload, aided by the PAB functional group. This linker is suitable for use in cancer research and therapeutic development.
Chemical Information
| Catalog Num | A43346 |
|---|---|
| M. Wt | 954.07 |
| Formula | C44H71N7O16 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2387738-43-2 |
| Synonyms | |
| SMILES | CC(C)[C@@H](C(N[C@H](C(NC1=CC=C(C=C1)CO)=O)CCCNC(N)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN(C(C=C2)=O)C2=O)=O)=O |
Biological Activity
| Description | Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker designed to facilitate targeted drug delivery in antibody-drug conjugates. The maleimide group enables covalent attachment to free thiols present on cysteine residues in proteins, while the hydrophilic PEG spacer enhances solubility and reduces immunogenicity. Upon internalization, the Val-Cit dipeptide is cleaved by cellular proteases, allowing for the efficient release of the therapeutic payload, aided by the PAB functional group. This linker is suitable for use in cancer research and therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
