Product Data Sheet
Boc-PEG4-Val-Cit-PAB-OH
Catalog No. A43366
Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs). This compound features a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide, facilitating the attachment of drug payloads through reactive groups such as PNP. The Boc group can be removed via acidic treatment, yielding a primary amine suitable for forming amides through coupling reactions. The Val-Cit-PAB component is preferentially cleaved by cellular proteases, enabling efficient release of the cytotoxic payload within targeted cells.
Chemical Information
| Catalog Num | A43366 |
|---|---|
| M. Wt | 726.86 |
| Formula | C34H58N6O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2055024-54-7 |
| Synonyms | |
| SMILES | CC(C)(C)OC(NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)CO)=O)=O)=O)=O |
Biological Activity
| Description | Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs). This compound features a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide, facilitating the attachment of drug payloads through reactive groups such as PNP. The Boc group can be removed via acidic treatment, yielding a primary amine suitable for forming amides through coupling reactions. The Val-Cit-PAB component is preferentially cleaved by cellular proteases, enabling efficient release of the cytotoxic payload within targeted cells. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
