Product Data Sheet
Fmoc-PEG2-Val-Cit-PAB-OH
Catalog No. A43387
Fmoc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable linker specifically designed for antibody-drug conjugates (ADCs). This compound features a hydrophilic PEG spacer and a Val-Cit-PAB dipeptide, which enables the selective release of therapeutic payloads inside target cells through proteolytic cleavage. The benzylic alcohol present in the PAB component can readily react with various functional groups for efficient conjugation to drug molecules, while the Fmoc protecting group can be deprotected using piperidine, allowing access to a primary amine for further coupling reactions. This linker is crucial for enhancing the efficacy and specificity of ADCs in biological research and therapeutic applications.
Chemical Information
| Catalog Num | A43387 |
|---|---|
| M. Wt | 760.88 |
| Formula | C40H52N6O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2055024-59-2 |
| Synonyms | |
| SMILES | OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O)=O |
Biological Activity
| Description | Fmoc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable linker specifically designed for antibody-drug conjugates (ADCs). This compound features a hydrophilic PEG spacer and a Val-Cit-PAB dipeptide, which enables the selective release of therapeutic payloads inside target cells through proteolytic cleavage. The benzylic alcohol present in the PAB component can readily react with various functional groups for efficient conjugation to drug molecules, while the Fmoc protecting group can be deprotected using piperidine, allowing access to a primary amine for further coupling reactions. This linker is crucial for enhancing the efficacy and specificity of ADCs in biological research and therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
