Product Data Sheet
t-Boc-N-amido-PEG4-Val-Cit
Catalog No. A43416
t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable linker designed for antibody-drug conjugates (ADCs). This compound consists of a Boc-protected amine, a hydrophilic polyethylene glycol (PEG) spacer, and a Val-Cit dipeptide that can be cleaved by cellular proteases. The resulting carboxylic acid facilitates coupling reactions with amines to form amides. Upon removal of the Boc group under acidic conditions, a free primary amine is available for diverse chemical reactions, including coupling and reductive amination, making it a versatile tool in ADC development and modification.
Chemical Information
| Catalog Num | A43416 |
|---|---|
| M. Wt | 621.72 |
| Formula | C27H51N5O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2231240-82-5 |
| Synonyms | |
| SMILES | NC(NCCC[C@@H](C(O)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O)=O)=O |
Biological Activity
| Description | t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable linker designed for antibody-drug conjugates (ADCs). This compound consists of a Boc-protected amine, a hydrophilic polyethylene glycol (PEG) spacer, and a Val-Cit dipeptide that can be cleaved by cellular proteases. The resulting carboxylic acid facilitates coupling reactions with amines to form amides. Upon removal of the Boc group under acidic conditions, a free primary amine is available for diverse chemical reactions, including coupling and reductive amination, making it a versatile tool in ADC development and modification. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
